Tangata EGFR Gene 29 Mutations
ingoa hua
HWTS-TM001A-Human EGFR Gene 29 Mutations Detection Kit (Fluorescence PCR)
Epidemiology
Ko te mate pukupuku o te pukahukahu te take matua o te mate pukupuku puta noa i te ao, e tino whakararu ana i te hauora o te tangata.Ko te mate pukupuku pūkahukahu kore-iti e noho ana mo te 80% o nga turoro mate pukupuku pūkahukahu.I tenei wa, ko te EGFR te tino whainga irapoi mo te maimoatanga o te mate pukupuku pukupuku kore-iti.Ka taea e te phosphorylation o EGFR te whakatairanga i te tipu o te pukupuku pukupuku, te rereketanga, te whakaeke, te metastasis, te anti-apoptosis, me te whakatairanga i te angiogenesis pukupuku.Ka taea e te EGFR tyrosine kinase inhibitors (TKI) te aukati i te huarahi tohu tohu EGFR ma te aukati i te autophosphorylation EGFR, na reira ka aukati i te tipu me te rereketanga o nga pūtau pukupuku, te whakatairanga i te apoptosis pūtau pukupuku, te whakaiti i te angiogenesis pukupuku, me etahi atu, kia tutuki ai te maimoatanga mate pukupuku.He maha nga rangahau i whakaatu ko te kaha o te rongoa o te EGFR-TKI e hono tata ana ki te mana o te ira ira EGFR, a ka taea te aukati i te tipu o nga pūtau puku me te ira ira EGFR.Ko te ira EGFR kei runga i te ringa poto o te chromosome 7 (7p12), he 200Kb te roa, he 28 exons.Ko te nuinga o te rohe kua whakarereke i roto i nga exons 18 ki te 21, ko nga codons 746 ki te 753 te whakakore i te huringa i runga i te exon 19 mo te 45% me te L858R i runga i te exon 21 mo te 40% ki te 45%.Ko nga Aratohu a te NCCN mo te Whakamatau me te Whakamohoatanga o te Matepukupuku Puku Puku-kore-iti e kii marama ana ko te whakamatautau ira ira EGFR i mua i te whakahaeretanga o te EGFR-TKI.Ka whakamahia tenei kete whakamatautau ki te arahi i te whakahaeretanga o nga raau taero epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), me te whakarato i te kaupapa mo te rongoa whaiaro mo nga turoro he mate pukupuku pūtau kore-iti.Ka whakamahia noa tenei kete mo te kite i nga huringa noa i roto i te ira EGFR i roto i nga turoro me te mate pukupuku pūtau kore-iti.Ko nga hua whakamatautau mo te tohutoro haumanu anake, kaua e whakamahia hei kaupapa mo te maimoatanga takitahi o nga turoro.Me whai whakaaro nga tohunga haumanu ki te ahua o te manawanui, nga tohu rongoa me te maimoatanga Ka whakamahia te tauhohenga me etahi atu tohu whakamatautau taiwhanga me etahi atu mea hei whakatau i nga hua whakamatautau.
Hongere
| FAM | IC Reaction Buffer, L858R Reaction Buffer, 19del Reaction Buffer, T790M Reaction Buffer, G719X Reaction Buffer, 3Ins20 Reaction Buffer, L861Q Reaction Buffer, S768I Reaction Buffer |
Tawhā Hangarau
| Rokiroki | Wai: ≤-18 ℃ I te pouri;Lyophilized: ≤30 ℃ I te pouri |
| Papa-ora | Wai: 9 marama;Lyophilized: 12 marama |
| Momo Tauira | te kiko pukupuku hou, te waahanga pathological tio, te kiko pathological kua whakauruhia he paraffin, te waahanga ranei, te plasma, te serum ranei |
| CV | <5.0% |
| LoD | te kitenga otinga tauhohenga waikawa nucleic i raro i te papamuri o te 3ng/μL momo mohoao, ka taea te kite i te 1% te reeti rereke |
| Tauwhāiti | Karekau he tauhohenga whakawhiti me te momo mohoao mohoao DNA ira tangata me etahi atu momo mutant |
| Nga taputapu e tika ana | Whakamahinga Biosystems 7500 Pūnaha PCR Wā-tūturuWhakamahi Biosystems 7300 Pūnaha PCR Wā-tūturu QuantStudio® 5 Pūnaha PCR Wā-tūturu LightCycler® 480 Pūnaha PCR Wā-tūturu BioRad CFX96 Pūnaha PCR Wā-tūturu |
Rere Mahi
