Tangata ROS1 Fusion Gene Mutation

Ko te ROS1 he tyrosine kinase transmembrane o te whanau kaikawe insulin.Kua whakapumautia te ira whakakotahitanga ROS1 hei ira taraiwa mate pukupuku pūkahukahu kore-iti.Hei māngai o te momo iti rāpoi ahurei hou, ko te paheketanga o te ira whakakotahitanga ROS1 i roto i te NSCLC Mo te 1% ki te 2% ROS1 te nuinga ka whakareri i te ira i roto i ona exons 32, 34, 35 me te 36. I muri i te whakakotahitanga ki nga ira penei i te CD74, EZR, SLC34A2, me SDC4, ka kaha tonu te mahi i te rohe ROS1 tyrosine kinase.Ka taea e te kinase ROS1 kua whakakorehia te whakahoahohia nga huarahi tohu o raro penei i te RAS/MAPK/ERK, PI3K/Akt/mTOR, me te JAK3/STAT3, na reira ka uru atu ki te whakatipuranga, te rereketanga me te metastasis o nga pūtau puku, me te mate pukupuku.I roto i te ROS1 fusion irakētanga, CD74-ROS1 kaute mo te 42%, EZR mo te 15%, SLC34A2 mo te 12%, me te SDC4 mo te 7%.Kua whakaatuhia e nga rangahau ko te waahi ATP-binding o te rohe catalytic o ROS1 kinase me te ATP-binding site o ALK kinase he homology ki runga ki te 77%, na te ALK tyrosine kinase iti mole ngota aukati crizotinib me etahi atu ka kitea he painga whakaora. i roto i te maimoatanga o te NSCLC me te whakawhitinga whakawhitinga o ROS1.No reira, ko te kitenga o nga huringa whakakotahitanga ROS1 te kaupapa me te kaupapa hei arahi i te whakamahinga o nga raau taero crizotinib.